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Drugs Solmux have composition Carbocisteine 500mg Salbutamol 2mg. Solmux for the symptomatic treatment of productive cough associated with acute and chronic, obstructive airway diseases, like acute and chronic bronchitis, bronchial asthma

Solmux Broncho : Capsule MUCOLYTIC-BRONCHODILATOR

Casalmux : Treatment of disorders of bronchial secretion, breathing difficulty

Ventolin : Treatment of acute severe asthma

PULMICORT : Treatment of bronchial asthma

1/ COMPOSITION

Each capsule contains:

Carbocisteine       500 mg

Salbutamol 2 mg

Excipients: Hydroxypropyl Methylcellulose, Starch, Pregelatinized Starch, Magnesium Stearate, Alcohol.

Solmux-Carbocisteine-Salbutamol

2/ PHARMACODYNAMICS

Carbocisteine, a derivative of Cisteine, is a mucolytic agent. It corrects the intracellular abnormalities of glycoprotein synthesis resulting in increased secretion of less viscous sialomucin and sulfoglycopeptides, and reduction of the highly viscous fucomucin content.

Carbocisteine normalizes the secretory functions of the mucosal epithelium and improves mucus flow from surface epithelial cells and subepithelial mucus glands.

Salbutamol stimulates Adenylcyclase which catalyzes cyclic-3’,5’-adenosine monophosphate from ATP. The cAMP thus formed mediates cellular responses such as relaxation of the bronchial smooth muscle.

3/ PHARMACOKINETICS

Carbocisteine is rapidly and well-absorbed after oral administration. Peak serum concentrations are reached in 1-2 hours. Plasma half-life is 1.5 to 2 hours. Carbocisteine penetrates well into lung tissues and respiratory mucus, suggesting local action. Carbocisteine undergoes acetylation, decarboxylation, and sulfoxidation. Majority of the drug is excreted unchanged in the urine.

After oral administration of Salbutamol, the most part passes through the liver and then into the blood and the absolute bioavailability is about 40%. Maximal plasma concentrations are reached 2-3 hours after the ingestion. Only 5% of the drug is bound to the plasma proteins. The half-life is 5-6 hours. About 50% is metabolized as inactive sulfoconjugates, 75-80% is excreted in the urine as active and inactive forms.

4/ INDICATIONS

For the symptomatic treatment of productive cough associated with acute and chronic obstructive airway diseases, like acute and chronic bronchitis, bronchial asthma

DOSAGE AND INSTRUCTION FOR USE

Orally, every 6-8 hours, or, as prescribed by a physician:

Adults         1 capsule / time

5/ CONTRAINDICATIONS

Known hypersensitivity to any of the components ot the product. Children under 2 years old.

6/ PRECAUTIONS

Consult a doctor if:

■       The cough persists for more than 3 weeks or if it gets worse.

■       The cough is accompanied by a recurring fever.

■       You experience upset stomach or heartburn after taking this product.

■       You have any new or unusual symptoms.

Pregnancy and lactation: The effects of Solmux Broncho when used during pregnancy or lactation are not known. Therefore, administer with caution to women during these periods. SIDE-EFFECTS

Solmux Broncho is generally well-tolerated. Adverse effects of carbocisteine are rare and include skin rashes, nausea, headaches, myalgia, dizziness and urinary incontinence. Gastrointestinal disturbance often occurs with acute overdosage. Salbutamol may cause tremor, palpitation, tachycardia. These effects are less observed in children. Tachycardia and digestive disturbance (nausea, vomiting) caused by high doses of salbutamol have been reported.

Please inform the doctor of all undesirable effects upon drug administration.

7/ OVERDOSE AND TREATMENT

The symptoms of salbutamol overdosage may include malaise, headache, dizziness, nausea, nervousness, limb tremor, tachycardia, cardiac arrhythmia, blood pressure change, convulsion. Hypokalaemia also may occur. Treatment consists of discontinuation of oral Salbutamol together with appropriate symptomatic therapy. In the event of serious poisoning, the stomach should be emptied and, if necessary, a beta-blocker administered with caution in patients with a history of bronchospasm.

8/DRUG INTERACTIONS

Concomitant administration with carbocisteine enhances the absorption of sodium amoxicillin. Pretreatment with cimetidine severely impairs the urinary elimination of carbocisteine sulfoxides. Concomitant intake of diuretics may enhance the hypokalemia that occurs with large doses of salbutamol. The effects of this drug are inhibited by beta-blockers. Salbutamol may increase blood glucose in patients using antidiabetic medicine.

9/PRESENTATION

Box of 25 strips x 4 capsules.

10/ STORAGE

Store at temperatures not exceeding 30°C.

SHELF-LIFE

24 months from manufacturing date.

Solmux syrup :

Solmux syrup

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