Drugs Klamentin 1g have composition Amoxicillin 875mg and Clavulanic acid 125mg. Klamentin 1g treatment of Upper respiratory tract infections, Lower respiratory tract infections , Urogenital it act infections caused by E.coli, Bone and joint infection such as endostitis, Odontology infection: alveolar abscess.

Cefdinir 300mg indications acute course of chronic bronchitis, acute sinusitis, pharyngitis, tonsillitis

Azithromycin 200mg indications respiratory tract infections, Skin and soft tissue infections

Clarithromycin is used for the treatment of pharyngitis and tonsillitis, disseminated infections


Amoxicillin (as amoxicillin trihydrate)   875 mg

Clavulanic acid (as clavulanate potassium)          125 mg

Excipients q.s    1 tablet

(Aerosil. potyplasdone XL, avicel M112. magnesium stearate, sepifilm, titanium dioxide, talc).

Klamentin 1g - Amoxicillin 875mg & Clavulanic acid 125mg


Film coated tablets.


Box of 2 blisters x 7 tablets.


Amoxicillin is a beta-lactam semi-synthetic antibiotic with a broad-spectrum of bactericial activity against many Gram-positive and Gram-negative microorganisms due to inhibition of bacterial cell wall. Amoxicillin is. however, susceptible to degradation by beta – lactamases and, therefore, the spectrum of activity does not include organisms which produce these enzymes.

Clavulanic acid has beta-lactam structure resembling that of penicillin. It is an inhibitor of beta-lactamases produced by Gram-negative bacteria and Staphylococcus. Clavulanic acid is particularly active against the plasmid medicated beta-lactamase frequently responsible for transferred drug resistance to penicillins and cephalosporins. The combination of clavulanic acid and amoxicillin in Klamentin help to protect amoxicillin from degradation by beta-lactamase enzymes, and effectively extends the antibacterial spectrum of amoxicillin to include many bacteria normally resistant to amoxicillin and microorganisms resistant to other penicillins and cephalosporins.The spectrum of activity:

Gram-positive bacteria:

Anaerobic Bacteria: Streptococcus faecalis, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus viridans, Staphylococcus aureus, Corynebacterium, Bacillus anthracis, Listeria monocytogenes.

Fastidious bacteria: Clostridium, Peptococcus, Peptostreptococcus.

Gram-negative Bacteria:

Anaerobic Bacteria: Haemophilus influenzae, Escherichia coli, Proteus mirabiiis. Proteus vulgaris, Klebsiella, Salmonella, Shigella, Bordetella, Neisseria gonorrhoeae, Neisseria meningitidis, Vibrio cholerae, Pasteurella muttocida.

Fastidious bacteria: Bacteroides including B. fragilis.


Klamentin 1g are well absorbed by oral administration and achieve the maximum serum concentrations after 1 – 2 hours. Absorption of Klamentin is not affected by food; Klamentin 1g should be taken right before meals. Oral bioavailability of amoxicillin is 90% and that of clavulanic acid is 75%. The serum half-life of amoxicillin is 1 – 2 hours and that of clavulanic acid is about 1 hour. Approximately 55% to 70% of the amoxicillin and approximately 30% to 40% of the clavulanic acid are excreted unchanged in urine. Concurrent administration of probenecid delays amoxicillin excretion but does not delay renal excretion of clavulanic acid.


For short-term treatment of:

Upper respiratory tract infections (consisting of ENT) such as tonsillitis, sinusitis, otitis media

Lower respiratory tract infections caused by beta-lactamase producing strains; H.influenzae and Branhametta catarrbalis such as acute and chronic bronchitis, chronic bronchopneumonia, pneumonia – bronchitis

Urogenital it act intections caused by E.coli. Klebsiella and Enterobacter such as cystitis. urethritis, pyelonephritis.

Skin anti soft tissue infections such as furuncles, abscesses, and infected wounds.

Bone and joint infection such as endostitis.

Odontology infection: alveolar abscess.

Other intections: septic abortion; obstetrical, intra-abdominal   infections,obstetric bleeding intections.


Hypersensitivity to penicillins and cephalosporins. Severe hepatic and moderate to severe renal impairment. A history of jaundice or hepatic dysfunction during receiving penicillin. Infectious mononucleosis.


Patients with moderate to severe renal impaired should be adjusted the dose.

Patients with a known history of jaundice or disorder of hepatic function who receive penicillin.

Patients with mononucleosis who receive amoxicillin develop an erythematous skin rash.

Prolonged use of Klamentin is reported to cause superinfection.


There is no evidence on the harms of Klamentin 1g in foetus; therefore, just use in really required cases during pregnancy. Caution should be exercised in nursing women.


The effect of Klamentin 1g on the ability to drive vehicles and operate machinery is rarely reported.


Probenecid decreases renal tubular secretion of amoxicillin: thus, it may result in increased blood levels of amoxicillin.

Klamentin 1g may prolong the bleeding and clotting time. Klamentin may reduce the efficacy of oral contraceptives.


Common: Diarrhoea, nausea, vomiting. Skin rash, ‘itching.

Less common: Eosinophilia. Hepatitis, obstructive jaundice, elevated transaminases. Itching, erythema, skin rash.

Rare: Anaphylactic reaction, Quincke oedema. Mild thrombocytopenia, hypoleukemia, hemolytic anemia. Pseudomembranous colitis, Stevens- Johnson, erythema multiforme, exanthematous pustulosis, exfoliative dermatitis syndrome. Interstitial nephritis.

Inform your physician about any adverse effects xcur during the treatment.


Following overdosage, Klamentin 1g rarely induces accidents because of its good absorption even high doses. However, some acute reactions depend on hypersensitive states in each individual. Risk of hyperpotassemia is reported when using high doses since clavulamc acid is used in the form of potassium salts. Both amoxicillin and clavunate are removed from the circulation by hemodialysis.


The doses are based on amoxicillin component. Klamentin 1g should be taken immediately before meals to reduce the drug intolerance in the stomach and intestine.

Adults and children aged > 12 years; severe infection: take 1 tablet twice daily, Patients with impaired renal function:

Creatinine clearance > 30 ml/min: do not require a reduction in dose Klamentin 1 g should not be used in patients with medium renal impairment. Duration of therapy is 5 -10 days and should not be exceeded 14 days without re-examination.

Or as directed by the physician.

Read the directions carefully before use.

Consult the physician for more Information.

Klamentin 1g is tor prescriptions oniy.

Shelf-life: 24 months from the manufacturing date.

Storage conditions:

Store in dry places, not exceeding 30°C, protect from light.

Specifications: Manufacturer’s.


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