Drugs Aticef 500mg have composition cefadroxil 500mg, treatment of mild to moderate infections : Respiratory tract infections, Tonsillitis, sore throat, otitis media, nasosinusitis, laryngitis, Bronchopneumonia, lobar pneumonia, Skin and soft tissue infections

Klamentin 1g treatment of  Lower and upper respiratory tract infections, Bone and joint infection

Clindastad 150mg used chiefly in the treatment of serious anaerobic infections

OpeCipro 500mg is indicated for severe infections, Gastrointestinal tract infections


Cefadroxil monohydrate equivalent to 500 mg cefadroxil

Excipients qs.   1 capsule

(Magnesium stearate, sodium starch glycolate. aerosil, talc).

DOSAGE FORM. Hard capsules.

Aticef 500mg - Cefadroxil monohydrate 500mg


Box of 2 blisters x 7 capsules. Bottle of 200 capsules.


Aticef 500mg contains the active ingredient Cefadroxil, a semi-synthetic antibiotic classified as the first generation Cephalosporin it has bactericidal action inhibits bacterial division and development by inhibition of synthesis of the bacterial cell wall Gram-positive bacteria including Staphylococcus (penicillinase-producing and non-penicillinase-producing), Haemolytic Streptococcus, Streptococcus pneumoniae, Streptococcus pyogenes Gram negative bacteria including Escherichia coli, Kleb-siella pneumoniae, Proteus mirabilis and Moraxeiia. Haemophilus influenzae are less susceptible


Aticef 500mg is stable in gastric acidity and well absorbed in gastrointestinal tract, it is not affected by food. About 20% of Cefadroxil is reported to be bound to plasma proteins. The plasma half-life of Cefadroxil is about 1.5 hrs in people with healthy renal function, and prolonged about 14 – 20 hrs in patients with impaired renal function. Right after being absorbed, Cefadroxil is widely distributed to the body tissues and fluids. It crosses the placenta and appears in breast milk. Cefadroxil is not metabolized. More than 90% of a dose of cefadroxil is excreted unchanged in the urine within 24 hours by glomerula filtration and tubular secretion. Cefadroxil is highly removed by haemodialysis.


Aticef 500mg For treatment of mild to moderate infections caused by susceptible bacteria:

–        Respiratory tract infections:

–        Tonsillitis, sore throat, otitis media, nasosinusitis, laryngitis.

–        Bronchopneumonia, lobar pneumonia, acute and chronic bronchitis, pulmonary abscess, empyema, pleurisy.

–        Urogemtal infections: cystitis, acute and chronic pyelonephritis, urethritis, gynecologic infections.

–        Skin and soft tissue infections: furuncles, erysipelas, lymphadenitis, abscess, cellulitis, ulcer caused by prolonged lying, mastitis.

–        Other infections: musculoskeletal inflammations, osteomyelitis, septic osteoarthritis, gynecologic infections.


Hypersensitivity to cephalosporin antibiotics.


Patients with known hypersensitive to penicillins. Patients with renal impairment (creatinine clearance rates <= 50ml/ min).

Prolonged use of cefadroxil 500mg may result in the overgrowth of nonsusceptible organisms. Careful observation of the patient is essential. If superinfection occurs during therapy, stop using the drug. Pseudomembranous colitis has been reported when administration of broad-spectrum antibiotics. The diagnosis of pseudomembranous colitis should be cautious in patients with severe diarrhea during or after taking antibiotics. Caution should be exercised in individuals with a history of gastrointestinal disease, particularly colitis. Experience use of cefadroxil in neonates and premature babies is still limited, cautions should be taken in these subjects.


Aticef 500mg should only be used in pregnancy and lactation if really need.


The effect of cefadroxil 500mg on the ability to drive vehicles and operate machinery is rarely reported.


Cholestyramine delays the absorption of cefadroxil. Probenecid decreases the secretion of cefadroxil. Concomitant use of cefadroxil with furosemide, aminoglycoside increases the nephrotoxic effect


Frequently: Nausea, abdominal pain, vomiting, diarrhea.

Less frequently: Eosinophilia. Urticaria, skin rash, prurigo. Reversible increases in transaminases. Testicular pain, vaginitis, Candida infection, genital Itching. Rarely: Anaphylactic reaction, serum disease, fever. Neutropenia, thrombocytopenia, hemolytic anemia, positive Coombs’ tests. Pseudomembranous colitis, gastrointestinal disorders. Stevens -Johnson syndrome, Lyell’s syndrome, angioedema. Obstructive jaundice, mild elevation of AST, ALT, hepatitis. Nephrotoxicity with transient increase in urea and plasma creatinine, reversible interstitial nephritis. Convulsion (when using high dose and in case of renal impaired function), headache, irritation. Joint pains.

Inform your physician about any adverse effects occur during the treatment.


Symptoms of acule overdosage: mostly nausea, vomiting, diarrhea. The possibility of hypersensitivity in muscle nerve and convulsion may occur, especially in patients with renal impairment. Treatment of overdosage is necessary to consider the possible overdose of many medicines, interactions and abnormal pharmacokinetics in patients. Haemodialysis may be useful in removing drug from circulating blood, but it is usually not indicated. Protect patients’ respiratory tract, assist respiration and infusion. Symptomatic treatment and supportive therapy are mainly applied after carrying out gastric lavage.


Orally taken before or during meals.

Adults and children weighing > 40 kg: 500 – 1000 mg (1 – 2 capsules) x 2 times daily.

Mild to moderate infections of respiratory tract, osteo-articulation: 500 mg (1 capsule) twice daily. Severe cases: 1000 mg (2 capsules) twice daily.

Skin and soft tissue infections: 1000 mg (2 capsules) once daily.

Children aged > 6 years: 500 mg (1 capsule) twice daily.

for patients with renal impairment: The doses should be adjusted in patients with renal impairment whose creatinine clearance rates s 50 ml/ min.

Initial dose; 500 -1000 mg (1 – 2 capsules).

Sequent doses can be adjusted as follows: Creatinine clearance rates 0 -10 ml/ min: 500 -1000 mg (1 – 2 capsules) every 36 hrs.

Creatinine clearance rates 11 – 25 ml/ min: 500 -1000 mg (1 -2 capsules) every 24 hrs.

Creatinine clearance rates 26 – 50 ml/ min: 500 -1000 mg (1 -2 capsules) every 12 hrs.

Treatment time should be maintained at least 5-10 days.

Or as directed by the physician.

Read the directions carefully before use.

Shell-life: 36 months from the manufacturing date.

Consult the physician for more Information.

Storage conditions: store in dry places, not exceeding 300 C, protect from light

Aticef 500mg is for prescriptions only.

Specifications: Manufacturer’s.


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